7 Papaya Enzyme Side Effects and Warnings
While there are many health benefits to eating papaya fruit, there are also important potential papaya enzyme side effects and warnings to be aware of.
This is particularly the case with regards to the green unripe fruit, papaya seeds, papaya leaf and papain enzyme digestive supplements.
Let’s have a look at 7 of the most common side effects of papain papaya enzyme and in what situations and conditions it would be best to avoid using it.
1. Pregnancy Precautions with Papaya
Green papaya latex, which is rich in the main papaya enzyme papain, has been traditionally used by various cultures in Asia to induce a miscarriage during pregnancy.
For this purpose it was often applied directly to the uterus, but food forms such as green papaya salad, the seeds of papaya in the parasite killing papaya seed smoothie ahead, as well as supplements containing papain enzyme are best avoided by pregnant women.
This warning does not extend to a fully ripe fresh fruit that are all yellow or orange with no green on it. These papaya fruit contain much lower levels of papain and are very healthy for pregnant women with their rich antioxidant and vitamin content and many other papaya health benefits.
2. Papain, Papaya Seeds and the Menstrual Cycle
Associated with the precautions of using papain when trying to become pregnant, papaya seeds, green papaya and other potent sources of papaya enzymes may interfere with a woman’s menstrual cycle if taken in large and regular doses.
One research paper on the subject suggested two possible mechanisms for how papain or associated enzymes within papaya seeds and green papaya could have an effect on normal menstruation.
According to the scientists, unripe papaya: “…contains the enzyme papain which suppresses progesterone, a hormone needed to prepare the uterus for conception and maintain pregnancy. Another possibility is that papain may break down a membrane vital to the development of the fetus”.
Once again, fully ripe papaya would not contain enough enzymes to have a significant effect on the menstrual cycle or a woman’s ability to get pregnant.
3. Papaya Enzyme and Breastfeeding
Some sources advise against using papaya enzymes, unripe papaya or even the ripe fruit during breast feeding, though no specific reasons or supporting research is given why.
Interestingly, green papaya salads and soups are popular across Asia as a galactagogue, a substance that increases milk flow from the breast. To this end, eating the fruit while it is still green and full of papain enzyme is often recommended for breastfeeding women.
4. Papaya Seeds as a Contraceptive for Men
Along with their well known effects on the reproductive cycles of women, papaya seeds in particular can affect male fertility and have been traditionally used as a form of birth control for men in some Asian cultures.
There’s a detailed look at using papaya seeds as a male contraceptive including supporting research here. Needless to say, a man trying to get his partner pregnant should avoid green papaya and papaya seeds.
5. Papaya and Stomach Ulcers
There are mixed reports from health resources regarding papaya enzyme and ulcers. On the one hand, people suffering from severe stomach ulcers are sometimes advised to avoid the fruit, particularly when it’s green, as well as any digestive enzymes with papain.
On the other, eating papaya with its many nutrients and enzymes is often said to help prevent gastric ulcers and heal minor stomach problems.
It may do this by both increasing the protective mucus secretions in the stomach and, due to its ability to speed up the breakdown of protein, lessening the amount of time hydrochloric acid sits in the stomach.
While the occasional ripe fruit should not cause problems, talk to your doctor if you are being treated for a stomach ulcer and are thinking of using papaya enzymes with papain for digestion.
As a natural alternative to pharmaceuticals, this superfood smoothie contains some excellent ingredients for healing ulcers and improving your overall digestive health.
6. Papain and Blood Thinning Medications
The papain enzyme may increase the blood thinning effects of medications such as Warfarin and other anticoagulants, including daily aspirin taken for this purpose. As such it is not recommended for use at the same time as a course of these drugs.
It is also very important not to take papain supplements, green papaya or papaya seeds for several days before major surgery for the same reason.
People with blood clotting disorders, such as thrombosis and hemophilia, are also advised to avoid papain and green papaya. In cases like these, and any of the above, it is best to discuss using papaya enzymes with a knowledgeable healthcare professional.
7. Papaya Allergies
Papaya and especially the green fruit high in enzymes should be avoided by anyone with a latex allergy.
Papaya allergies are rare, but people who experience allergic reactions to papaw may also have an adverse reaction to pineapples, avocados, bananas, figs, kiwi fruit, melons and possibly other tropical fruit as well and should use any of these with caution and watch for symptoms.
Allergic reactions symptoms, while once again very uncommon, can include: swelling or itching of the face, lips, tongue and throat; rashes that appear shortly after consumption; dizziness; difficulty swallowing; and abdominal pain.
There may be other side effects of a papaya or latex allergies so seek medical advice as soon as possible if you have any unusual reactions after eating any of the fruit listed above.
For the vast majority of people, papaya and the enzymes from the unripe fruit are extremely beneficial and a very healthy addition to your diet. Effective green papaya digestive enzyme powder is available if you can’t get the fresh fruit all the time, but I’d still recommend looking out of it and trying it when you can.
Papaya Leaf as a Treatment for Dengue, Malaria and Cancer
Papaya leaf is a natural treatment for dengue fever and malaria. It is particularly useful for dengue as there is currently no drug based treatment for the disease. It is also used as a cancer treatment in some natural therapies.
While many people have found papaya leaf juice or tea effective, the papaya enzyme warnings and potential side effects on this page would be especially relevant with the potency of papaya leaf.
Pregnant women in particularly should avoid all forms of papaya leaf and anyone being treated for ulcers or with blood thinning medication should consult their doctor before using it.
Papaya Enzyme Experiences
Do you have any experiences with using papaya enzyme that you’d like to share? I’d be interested to hear how it worked for you personally, both as a digestive aid and for other health improving purposes.
Next is a look at the unusual benefits of papaya seeds, an even stronger source of papain and other enzymes and alkaloids, and how to use them to improve your liver health, intestinal environment and even as a treatment for parasites.
Photo 1 credit: waywuwei
Last Updated on
This article may contain affiliate links to products I recommend. As an Amazon Associate I earn from qualifying purchases.