7 Papaya Enzyme Side Effects and Warnings

Side effects of Papaw enzymeWhile there are many benefits to eating papaya fruit, there are also important potential papaya enzyme side effects and warnings to be aware of.

This is particularly the case with regards to the green unripe fruit, papaya seeds, papaya leaf and papain enzyme digestive supplements.

Let’s have a look at seven of the most common side effects of papain papaya enzyme and in what situations and conditions it would be best to avoid using it.

1. Pregnancy Precautions with Papaya

Green papaya latex, which is rich in the main papaya enzyme papain, has been traditionally used by various cultures in Asia to induce a miscarriage during pregnancy.

For this purpose it was often applied directly to the uterus, but food forms such as green papaya salad, the seeds of papaya in the parasite killing papaya seed smoothie ahead, as well as supplements containing papain enzyme are best avoided by pregnant women.

This warning does not extend to a fully ripe fresh fruit that are all yellow or orange with no green on it. These papaya fruit contain much lower levels of papain and are generally considered very healthy for pregnant women with their rich antioxidant and vitamin content and many other health benefits.

2. Papain, Papaya Seeds and the Menstrual Cycle

Associated with the precautions of using papain when trying to become pregnant, papaya seeds, green papaya and other potent sources of papaya enzymes may interfere with a woman’s menstrual cycle if taken in large and regular doses.

One research paper on the subject suggested two possible mechanisms for how papain or associated enzymes within papaya seeds and green papaya could have an effect on normal menstruation.

According to the scientists, unripe papaya: “…contains the enzyme papain which suppresses progesterone, a hormone needed to prepare the uterus for conception and maintain pregnancy. Another possibility is that papain may break down a membrane vital to the development of the fetus”.

Once again, fully ripe papaya would not contain enough enzymes to have a significant effect on the menstrual cycle or a woman’s ability to get pregnant.

3. Papaya Enzyme and Breast Feeding

Some sources advise against using papaya enzymes, unripe papaya or even the ripe fruit during breast feeding, though no specific reasons or supporting research is given why.

Interestingly, green papaya salads and soups are popular across Asia as a galactagogue, a substance that increases milk flow from the breast. To this end, eating the fruit while it is still green and full of papain enzyme is often recommended for breastfeeding women.

Many Asian women also eat green papaya salad regularly, even when not breastfeeding, believing the papaya enzymes in it can lead to an increase in breast size over time.

Green papaya enzymes

4. Papaya Seeds as a Contraceptive for Men

Along with their well known effects on the reproductive cycles of women, papaya seeds in particular can affect male fertility and have been traditionally used as a form of birth control for men in some Asian cultures.

There’s a detailed look at using papaya seeds as a male contraceptive including supporting research here. Needless to say, a man trying to get his partner pregnant should avoid green papaya and papaya seeds.

5. Papaya and Stomach Ulcers

There are mixed reports from health resources regarding papaya enzyme and ulcers. On the one hand, people suffering from severe stomach ulcers are sometimes advised to avoid the fruit, particularly when it’s green, as well as any digestive enzymes with papain.

On the other, eating papaya with its many nutrients and enzymes is often said to help prevent gastric ulcers and heal minor stomach problems.

It may do this by both increasing the protective mucus secretions in the stomach and, due to its ability to speed up the breakdown of protein, lessening the amount of time hydrochloric acid sits in the stomach.

While the occasional ripe fruit should not cause problems, talk to your doctor if you are being treated for a stomach ulcer and are thinking of using papaya enzymes with papain for digestion.

As a natural alternative to pharmaceuticals, this superfood smoothie contains some excellent ingredients for healing ulcers and improving your overall digestive health.

6. Papain and Blood Thinning Medications

The papain enzyme may increase the blood thinning effects of medications such as Warfarin and other anticoagulants, including daily aspirin taken for this purpose. As such it is not recommended for use at the same time as a course of these drugs.

It is also very important not to take papain supplements, green papaya or papaya seeds for several days before major surgery for the same reason.

People with blood clotting disorders, such as thrombosis and hemophilia, are also advised to avoid papain and green papaya. In cases like these, and any of the above, it is best to discuss using papaya enzymes with a knowledgeable healthcare professional.

7. Papaya Allergies

Papaya and especially the green fruit high in enzymes should be avoided by anyone with a latex allergy.

Papaya allergies are rare, but people who experience allergic reactions to papaw may also have an adverse reaction to pineapples, avocados, bananas, figs, kiwi fruit, melons and possibly other tropical fruit as well and should use any of these with caution and watch for symptoms.

Allergic reactions symptoms, while once again very uncommon, can include: swelling or itching of the face, lips, tongue and throat; rashes that appear shortly after consumption; dizziness; difficulty swallowing; and abdominal pain.

There may be other side effects of a papaya or latex allergies so seek medical advice as soon as possible if you have any unusual reactions after eating any of the fruit listed above.

For the vast majority of people, papaya and the enzymes from the unripe fruit are extremely beneficial and a very healthy addition to your diet. Effective green papaya digestive enzyme powder is available if you can’t get the fresh fruit all the time, but I’d still recommend looking out of it and trying it when you can.

Papaya Leaf as a Treatment for Dengue, Malaria and Cancer

Papaya leaf is a natural treatment for dengue fever and malaria. It is particularly useful for dengue as there is currently no drug based treatment for the disease. It is also used as a cancer treatment in some natural therapies.

While many people have found papaya leaf juice or tea effective, the papaya enzyme warnings and potential side effects on this page would be especially relevant with the potency of papaya leaf.

Pregnant women in particularly should avoid all forms of papaya leaf and anyone being treated for ulcers or with blood thinning medication should consult their doctor before using it.

Papaya Enzyme Experiences

Do you have any experiences with using papaya enzyme that you’d like to share? I’d be interested to hear how it worked for you personally, both as a digestive aid and for other health improving purposes.

Next is a look at the unusual benefits of papaya seeds, an even stronger source of papain and other enzymes and alkaloids, and how to use them to improve your liver health, intestinal environment and even as a treatment for parasites.

Photo 1 credit: waywuwei 


Can Papaya seeds treat blood clotting disorders?

sunn yu

how to use papaya leaf extract for cancer?


Buenos días!
Me haría el favor de decirme si esta bien que estoy tomando Enzimas de Papaya en pastillas? Las comencé a tomar por que sentía que mi excremento me dejaba residuos al rededor del ano.
También si me podría decir si mi hijo las puede tomar. Él tiene 32 años, tiene molestias en el ano y le pica.
Muchas gracias.
Griselda Muñoz V.

Laurie Way

I was at a farmer’s market and was told to make papaya and blueberry smoothies with the greek yogurt as a change. Later that evening my husband cut it up so we could freeze some and try out our new fruit. The seeds smelled like dirty feet. Is this normal? The papaya I rinsed off well with cold water and that was fine. But the seeds baffeled me.

    Jim Dillan

    Hi Laurie,

    The seeds don’t taste great by any means but I wouldn’t describe the smell that way. You’d want to make sure there wasn’t any chance of mold but they will taste and smell very different to the fruit of the papaya. Wasabi would probably be the closest comparison I can think of.

    Hope this helps.


    I never tried papaya because it always smelled foul to me but after traveling to South America I ordered a fruit salad that came with chunks of papaya and decided to try it out. After a few fruit salads while on vacation, I now love papaya and try to eat it a few times a month back home.

      Jim Dillan

      Hi Jimmy,

      It’s funny how many people don’t like the smell of papaya. I personally love both the taste and the smell of it.

      All the best.


      Until today I still can’t eat ripen papaya on it own without some lime juice on it. This helps to kill the smell.


    Hi Jimmy,

    It’s funny how our taste works. I had the same experience with papaya and dirty feet described it perfectly for me early on. Now after persevering and forcing in down a few times, turns out I love it, and funny enough I no longer equate the smell with dirty feet.

    I had a similar more extremem experience with Durian. Honestly it smelled like poo to me.
    I avoided it many times till a Girlfriend insisted and insisted and… well I tried it, once, twice, by the third time I was hooked. It is now my favourite fruit and when I walk past a fruit stand selling it lo and behold the smell of poo has been replaced with a mouth watering aroma which calls buy me I’m delicous 🙂

      Jim Dillan

      Hi Jules. I’ve heard of a few people changing their opinion of the smell of papaya once they’ve tried it. Apparently the digestive enzymes may be responsible for this. It’s good that you’re enjoying such a healthy fruit now.

      All the best.


What about papaya enzymes with someone who has Neuroendocrine cancer. Rumors in the liver.


i am a patient of chronic pacreatatis aged 36 since 2004 , had undergone ERCP 2 times. whenever i used to eat banana since 1992 i experienced severe abdominal pain. now since 6 months i experience abdominal pain when i eat papaya. daily i consume one tablet of creyon 10000 while taking meal i also take homeopathy medicine which is very effective. What could be the reason for this allergy.

    Jim Dillan

    Hi Nilima,

    Apparently allergies to one tropical fruit like banana often affect your ability to eat others. I’d recommend seeing a knowledgeable healthcare professional as this may affect other related fruits as well.


Hi Jim its been 6 days of treatment eating paw paw seeds 1st thing in the morning on an empty stomach with a little help of raw honey. I’m not feeling nausea today. Definitely noticing the change of my tongue colour. I am aware you have to feel ill before the full effect as the parasites release toxins which are inside me.

    Jim Dillan

    Hi Sharon,

    I tend to think the detox reaction doesn’t need to be too strong and it’s best to lessen the dosage a little if symptoms are too uncomfortable. Longer regular treatments at smaller dosages can be just as good without the side effects. The change in the tongue color is good and it’ positive that you’re no longer feeling nausea. I’d continue with the timetable described in this article if you can – https://superfoodprofiles.com/papaya-seeds-parasites Papaya seeds can also be frozen for longer term storage if needed.

    Hope this helps.


I love papaya, I noticed that every time I eat it I have bad stomach ache. No other symptoms. Usually I eat yellow/ green papaya. Is it because that? Is it have to be completely yellow? I hate to stop eating it.

    Jim Dillan

    Hi Kasia,

    It is likely due to the high levels of papain enzyme in still green papaya which some are sensitive to. I’d try having it fully ripe and see if you still have the same problem.

    Hope this helps.

      Honey KNoles

      Looked up side effects of omeorazole ,told to take for acid reflux, would rather try to help chest pain with papaya enzyme chewable tablets. Do you think it would help?

        Jim Dillan

        Hi there,

        Many people find papaya enzymes effective for acid reflux, especially when impaired protein digestion is responsible for the condition. There’s more on how they work here – https://superfoodprofiles.com/papaya-enzymes-digestion

        Hope this helps.

        Helen T

        @ Honey… try slippery elm powder, mixed into a very stiff paste with a little honey and rolled into balls makes a great acid reflux portable treatnment if you pop them into an old vitamin tub. Also look up asafoetida/hing a spice that can be mixed in a little warm water, these may be a little more portable solutions than papaya.


        Hi Honey ~ saw your post on superfoodprofiles on one of the pages about papaya (warnings). You mention being prescribed a drug for acid reflux (presumably by an allopathic doctor. I have some good news for you because I have been studying this issue a bit mainly from a book called:
        ‘Why Stomach Acid is Good for You ~ Natural Relief from Heartburn, Indigestion, Reflux & GERD” by long time practicing functional medicine doctor Jonathan V. Wright. Original edition published in 2001. I would try to get a copy and read it! You will then come to understand that for the vast majority of folks “acid reflux” is really a misnomer as that is not in most cases what is going on at all! In fact its the opposite – not enough stomach acid especially for protein digestion, so for that papain enzymes would help you. But, the problem is bigger than that & many people need to correct their whole gut environment not just what is going on with the stomach. Dr. Wright outlines the basic natural treatments he has so successfully used with his patients over the years, many who were suffering from more severe problems because the real cause went unresolved for so long AND in some were greatly exacerbated by the prescription ant-acid meds they had been put on. I hope you are finding some relief with the papaya, but you may very well need to do other things as well, so I hope you can find Dr. Wrights book! And, I hope this helps!



I’ve been having a lot of trouble with abdominal cramps and diarrhea, especially after I eat. Someone suggested taking papaya enzymes. Would the papaya enzymes help with that? Thanks for any help you can give me.

Nina in PR

I have recently used raw papaya seed to help protein digestion since I have a problem with my gall bladder. I was having it several times a day, chewed up with water, maybe a teaspoon each time. I think that this may have altered my menstrual cycle (normally I am very regular) since my period came two weeks early, around the time I would normally ovulate. I assume this is “break through bleeding” and assume that the papain diminishes women’s estrogen levels. Could this be its contraceptive mechanism in women?

    Jim Dillan

    Hi Nina and thanks for your question.

    Papaya seeds and their papain are used traditionally to prevent pregnancy as described in the article so may indeed have an effect on the menstrual cycle in large doses. This effect is said to be temporary and completely reversable but it sounds like it would best to take a weeks break from the treatment and try a half dose in the following week to see if it has the same effect the next month if you want to continue with the treatment.

    Hope this helps.

Audrey Wint

Green Papaya can be used to treat bed sores or any cuts that is not healing properly. This method is used by Jamaican doctors after an operation.

1. Grate the green papaya using sterilized utensils. Extras must be stored in a sterilized bottle in the fridge.
2. Clean the wound thoroughly with saline
3. Wrap the grated papaya in sterilized gauze ensuring that it does not touch the skin as rash may develop leading to further sores
3. Insert the green papaya wrap inside/over the wound.
4. Cover with 2 or 3 layers of sterilized gauge and tape over
5. Change dressing everyday or every other day

I guarantee you that you will see results

    Jim Dillan

    Hi Audrey and thank you for the excellent information. Green papaya really is an amazing natural healer.

    All the best.


Hello! Jim,

Thank you for the research you’ve done and making this site available.

My sister was diagnosed with pancreatic cancer a couple of weeks ago. The doctor gave her 3 months. We were told it’s in the pancreas, liver, gallbladder and 8 tumors floating around in her colon.

My sister has always been on the typical American terrible diet all her life. She does eat salads, fresh fruit and out of the garden this time of year, which is good. But she eats all the bad foods too. However, she has decided against chemo/radiation which the doctor will not give her anyway because she continues to loose weight and her digestive tract is still not working well. But even with doctors saying get your digestive-tract corrected and gain-weight to start chemo/radiation she’s decided she will not be able to endure the painful sickness it will cause. She cannot handle the pain she now has and depends on the drugs to relieve her pain.

So she has decided she will change her diet. Besides the pain-pills the doctor also has her on pancreatic enzymes. I have been searching for food-sources of pancreatic enzymes but only have found the pharmaceutical type.

I woke this morning at 3AM with papaya and banana smoothy on my mind. I’ve searched for such a thing as helpful for her condition. I found your site as you see, but find no mention of bananas.

Could you suggest a diet for my sister please. Or if there is anyone on this site who has been cured of pancreatic cancer or knows of someone who has, would you please let me know the diet and the therapy used?

I am a strong believer in positive thinking, affirmative prayer, a joyous-heart and a Higher-Power/GOD for healing. Up until now the spiritual and pain-pills is all my sister has depended on. Though, now she is open to alternative/holistic means. My family and I are praying and believing in healing-guidance and perfect health for my sister. That guidance may come through your research and/or someone here… I have ears to hear.

Thank you for any help you can suggest!

    Jim Dillan

    Hi WandaKay,

    I would be important to discuss taking the smoothie treatment with her physician and having it well away from any medications but it is indeed a good source of proteolytic enzymes like papain and bromelain from pinapple cores. Bananas would be good to add too to this recipe if she’s losing weight so if the doctor says it’s ok then you could make it up with these as an extra ingredient – https://superfoodprofiles.com/papaya-seeds-parasites

    If she does decide to have the papaya seeds as well then start slowly with perhaps just a quarter of a teaspoon and increase the dose slowly if this is well tolerated.

    I’d also suggest investigating what has worked for others with her specific condition in terms of holistic healing on Curezone.org

    I really hope this can help and all the best in her healing.


    Hi can I use papaya leaf if i am breastfeeding a 2 month old baby

      Jim Dillan

      Hi Tabitha,

      You’d have to consult pediatrician on this as it’s often advised to avoid many herbs during breastfeeding and papaya leaf would be considered a potent herbal remedy.

      Hope this helps,



    I’m not sure how old this message is, I hope it’s recent and that your sister is doing well. When my father was going thru something sitar, cancertutor.com was an amazing resource, lots of different treatment options for even the most aggressive cancers.


I just want to add that eating the seeds of a papaya should only be done in small doses…I didn’t do enough research and made the bad decision to add a whole peeled papaya to a smoothie and have been in extreme discomfort for over 24 hours now. I’m sure i’m going to be fine but it is NOT pleasant nor recommended!

    Jim Dillan

    Hi Ilima,

    Yes that’s definitely too much to start with. As I mention in all of the papaya seed posts just a teaspoon is generally a good starting amount.

    All the best


I know that herbal ginger tea and chewable papaya enzyme tablets help with digestive troubles… I got food poisoning from the country club here in town last weekend from eating their undercooked chicken and was sick all week. I went online to see what I could do because I was getting worse and had symptoms of gastroparesis. (food staying in my stomach and burning pain) Instead of going to a dr and getting expensive tests done and loaded down with medication I decided to go online and see if there was something I could do at home. I found several websites by medical and herbal doctors and they all suggested the papaya enzyme and ginger tea. I’ve been using these for three days now and they have been working since I started. I don’t have the sick to my stomach feeling or nausia as long as I drink the tea and I can eat again!
I’m thankful that natural things that God made works!
also, since doing this, started friday morning, my blood glucose has been under 100, before meals. (I have diabetes 2) it hasn’t gone that low for like 10 years or more. one of the effects of ginger it says helps with glucose levels. I’m wondering if the ginger tea is doing this..
I am feeling ALOT better! sticking with bland food and small meals for a while.
I am no longer having to stay near the bathroom!

I would like to ask, how many papaya enzyme chewables are safe to take in a day? It says serving size 4 and to take them all with a meal but is it safe to take them with say, 2 meals a day?
thanks for this website and information!

    Jim Dillan

    Hi Dee,

    Glad they are working so well for you. There shouldn’t be a problem with taking them with 2 meals a day. Meals high in protein would be the best to take papaya enzymes with as well.

    Hope this helps,



If papaya seeds have thinning the blood properties, why cant we take them as a herbal remedy instead of taking the chemical blood thinning ‘medicines’

    Jim Dillan

    Hi Joey,

    There’s many natural substances that have blood thinning properties and would likely be healthier and safer than chemical drugs. Regardless, many people are on these prescriptions and it’s right for online writers to warn people of potential interactions.

    All the best.

Patricia Grace

Hi Jim
I’m originally from Africa therefore, somewhat was taught to recognize the symptoms of having a parasite. After feelinga crawling feeling in mt rear end I decided to make the papaya seeds smoothie yesterday. The taste was bareable but I felt as if ther was a lot of something is now sitting and crawling by my rear end. I feel bloated, so bloated that It unnconfortable sit to sit, lay down or walk.OMG..So late last night I decided to chew some papaya seeds and get it over with (all seeds from half a papaya). Again, I’m extremely bloated, gassy, the crawling at my rear end won’t stop, i feel i want to use the bathroom but I can’t go. I feel a tingling feeling inside my legs and again iam unconfortable. I am even tempted to visit the ER. I don’t know what to do. However, I noticed that my urine was bright yellow. I usually go once or twice a day. After eating activia, it stopped and I haven’t felt like myself for 6 days now.

    Jim Dillan

    Hi there and sorry for the late reply as I’ve been away.

    It sounds like the papaya seeds have caused pinworms to migrate out. Clove oil on a cotton wool bud applied to the anus can kill pinworms and their eggs but you may need to dilute it and should test on a small area first.

    The seeds from half a papaya is quite a lot and could bring on a bad reaction. Regular doses of the amounts suggested in the article are better for a treatment program with less side effects. I’d suggest visiting a parasite specialist if possible if you continue to get this kind of reaction. While many like myself prefer natural parasite treatments if you are getting this type of reaction it may be better to look at pharmaceutical options.

    All the best,



      If papaya seed and green papaya can caused mis-carriage/abortion and expelled parasite from the body. Can it expelled fibroid out from the womb? What can someone use to bring back menstration and what to use to improved fertility. Thank you.


I read recently that papain induces anti-kidd antibody production. Does it induce any other anti-bodies? I have an auto-immune disease and use papain as part of a digestive support supplement. Any thoughts..?

    Jim Dillan

    Hi Rachel,

    There looks to be a few mouse studies in google scholar on this but nothing conclusive I’m afraid.

    All the best,



Can papaya enzymes break down fibrin in blood vessels

Htar Htar Oo

when I suffered from cervical spondylosis I took green papaya milk from fresh fruit twice a day for only a few days and my severe pain went away. I did not take any pain killer. It’s worth to try.

    Jim Dillan

    Hi there and thanks for your comments.

    It’s interesting to hear that you found papaya enzymes effective for cervical spondylosis.

    All the best,



What will happen if i eat papaya during menstrual time.

    Jim Dillan

    Hi Varsha,

    Regular papaya should have no effect. A lot of green papaya may stimulate menstruation in some circumstances.

    Hope this helps,



I have eaten one uripe green pappaya long back 4 yrs before only once is it a problem to conceive . Now weight is gained around waist is it causes poly cystic ovary syndrome. I have also gained weight now from 43 kg to 56 kg. Pls reply that all these 3 causes infertility to me

    Jim Dillan

    Hi there,

    Just eating one green papaya would definitely not cause these symptoms. Green papaya is not recommended when you are pregnant but has no long term effects on fertility. Some stomach pain and perhaps a need to visit the bathroom are usually the only problems with having too much green papaya. Many Asian cultures eat it regularly.

    All the best,



Hi Jim,

Is it healthy to take a teaspoon of papaya seeds every morning for general health? Been doing for the past week and I plan to continue to do so for general digestive cleansing.



Lars Stiddem

Hi Jim,

Are the benefits of papaya papain diminished or decreased by eating the dehydrated fruit verses ripe? If so, by what degree?

Thank you for your research

    Jim Dillan

    Hi Lars,

    I’d suspect that dried papaya would be made from the ripe fruit and be low in papain and other digestive enzymes. Fresh papaya that’s more green than yellow would be a much better source.

    All the best,



hi, can you take papaya extract if you are on blood pressure tablets and or thyroid tablets.

    Jim Dillan

    Hi Shirley,

    You’d have to consult a healthcare professional on this about your individual situation. The papain enzyme is known to affect the blood so it would be important to check.

    All the best,



Thank God I found your site. I was using green paw paw powder to break down protein in my battle with cancer. The problem was I was unaware it is dangerous with blood thinning meds, I was on asprin and carnivore – both thin your blood. I ended up with severe mouth, stomach and intestinal ulcers. The pain was terrible for weeks. I was not under the care of a health practitioner that had any idea what to do. I could not eat for over two weeks and could not even take water for a few days and then only sips. I was very sick. I stopped everything till I did more research myself……. I am on the mend now..but it was a rough ride. Thanks again .. the place I purchased the green paw paw powder from had no warnings with the product. It is hard sometimes to find help when the doctors know nothing and you are on your own. Today I found a health practitioner who is helping me.

    Jim Dillan

    Hi Ray and sorry to hear you had this experience.

    Yes as the article says papaya enzymes can have a mild blood thinning effect which can be beneficial for some people but was obviously far too much when combined with the medications. Always keep natural treatments and pharmaceuticals well away from each other as there can be unforeseen consequences and, as you are doing now, please everyone always consult a knowledgeable healthcare professional when you are facing serious disease.

    All the best in your healing,



Hi, am a known ulcer patient & I’ve had several surgeries to. I read about the benefits of papaya juice & went ahead to take the unriped juice orally for 2 days thinking that it might work well on my intestines since I’ve had intestinal problems & obstructions & I came down with severe stomach cramps, ending up in the hospital.

    Jim Dillan

    Hi Joy and sorry to hear you had this experience.

    As it says in the article ‘people suffering from severe stomach ulcers are sometimes advised to avoid the fruit, particularly when it’s green, as well as any digestive enzymes with papain.’ and ‘talk to your doctor if you are being treated for a stomach ulcer and are thinking of using papaya enzymes with papain for digestion.’

    While papaya enzymes are believed to be helpful for preventing stomach ulcers they aren’t recommended if you already have them. It’s always worth checking with a healthcare professional if you are being treated for health conditions as the same powerful properties that make treatments like papaya enzymes beneficial for some can be problematic for others.

    All the best,




To my great surprise and shock, after 4-5 minutes she was feeling very itchy on her face.

I asked her to remain calm till the milk and pulp gets dry. but she was feeling so itchy, that she washed up her face immediately.

after fifteen minutes her skin was showing burn marks and itchiness was there on that spot.

I don’t know what to do now.
please advise.

    Jim Dillan

    Hi Prashant,

    Green papaya latex and pulp is full of papain, the protein digesting enzyme. While it is sometimes used on warts to break them down it’s too strong to be applied directly onto facial skin. Warm soapy water should remove it and aloe vera may help it to heal more quickly.

    All the best,



I tried to get this article unblocked by Pinterest & after several messages back & forth they seem to be sticking to their decision to block:

Bedford (Pinterest Help)

May 14, 14:35

Hi Isabel,

I’m really sorry about that! Unfortunately this website has been involved with spammy activity on Pinterest. As a result, we’ve blocked Pinning from their site. We appreciate your understanding.


Bedford | Community Specialist

I have no idea what constitutes “spammy activity”.

    Jim Dillan

    Hi Isabel and a big thank you for trying.

    I did have a Pinterest account and pinned a mixture of health articles every few days which is surely what most website owners would do. From what I’ve read it seems anyone can report a site, whether a competing website or just someone who doesn’t like natural remedies, and Pinterest blocks the site without considering whether it offers any value. It’s happened to many great sites and is very disappointing.

    I really do appreciate that you got in contact with them though.

    All the best,



unripe papaya can still cause miscarriage for 3 months pregnancy?

Anonymous age 73

Very interesting page. You wanted other uses of papaina and here is one. Years ago, a Boy Scout leader in the USA kept capsules of tenderizer in the troop first aid kit for bee stings. Unable to find liquid tenderizer anywhere, I bought the powder.

After I moved to Mexico, I got stung by a scorpion. I put on a paste of that tenderizer powder (by McCormick, and contains papaina) over and over and after ten minutes the stings effect was completely gone. I told my friends and neighbors about it.

Last week, I was recalling that event and suddenly realized I had been ingesting a modest quantity from my fingers with each application of the paste. And, the time to ‘cure’ the sting was about the time for the papaina to move into my blood stream.

The next day (last week) I got bit on a knuckle by an unknown insect, and the entire knuckle turned bright red, so it was more than a mosquito bite. I started ingesting small quantities of tenderizer and in ten minutes the red was all gone.

I thought that over. I have been having higher than normal blood pressure, very clearly connected with massive insecticide contamination of vegetables in Mexico, and of lard and goat fat where they graze fields which were sprayed for vegetables. (Insecticide is absorbed by fat.) If you want to know about insecticide problems, look for “organophosphate poisoning” on wikipedia. With experience I can tell when my veggies were contaminated, because my eyes start watering and my b.p. goes up a ways.

I thought if papaina neutralizes organic venom it might have an effect on other organic poisons.

So, I decided to use McCormick tenderizer instead of regular salt on my food. Not knowing side effects of tenderizer, I kept my usage on the low side until I get confidence. My b.p. within 2 days dropped as low as 110/75. Perfect for me is 105/65.

After two days like that, I stopped the tenderizer, because each batch of vegetables is different as far as insecticide is concerned. I wanted to eliminate the possibility that the reduction in b.p. was related to less contamination. By the second day, b.p. was back up to 129. This short experiment is not solid proof, but it is enough that I will keep on for the present. The reason I came to this page was looking for the dangers of ingesting tenderizer. I am hypoglycemic and do normally consume a lot of salt so that part (iodized salt) of tenderizer is not a problem.

Note that at my age, 73, average b.p. per Guyton and Hall (a physiology text book used by some med schools, you can buy it used on Amazon) is around 165/95. My diet is a modified Atkins diet which explains the low b.p.

I am highly experienced on elimination diets, so will monitor things very closely.

Anonymous age 73

I forgot something very important. A cousin here in Mexico is an expert on natural plant medicines. He said a traditional treatment for scorpion stings was to make a poultice of papaya leaves and put it on the sting.


I really appreciate the info you have on here and your responses that you have made. I have a parasitic infection and even though the parasites are visible as worms on my clothes and what I call “hatchlings” (small white insect-like, occasionally with rear appendages), I have gone through 5 doctors in the the Midwest, one fecal lab and one comprehensive one, and the results have been that I am now certifiably nuts. My primary doctor of thirty-five years refused to treat me, his replacement just smiles when I try to point out the infestation. I found a wellness clinic who at least tried, but after a gastro doc said it was hair, she is not even giving me my last test results (which I am assuming is negative). I have tried everything listed on Curezone, including horsepaste, menbendazole, albenzadole, and pyrantel. (Yes, you can get this and Vermox without a prescription–but I don’t advise it as my kidneys have taken a hit after 3 years.) And while I have eaten lots of papaya seeds, pumpkin seeds, cloves, garlic, coconut oil and water, I can’t wait to try your smoothie. I am having good luck with Yerba Prima Women’s Renew, and Bentonite products, and Paristall from Naturaly (sic) Pure which is a combination of Chinese herbs. Unfortunately, I have never had a reinfestation because I have never cleared them out completely to start with. And by the way—papayas are plentiful in the Midwest. I don’t know what Columbus, Ohio, is thinking except maybe they don’t know what they look like–instead of so many pictures of seeds, how about an exterior shot? Kroger and Miejers both carry them currently for under $2.50 (and have for the three years I have been fighting this campaign). Again, THANK YOU THANK YOU THANK YOU for your concern and your knowledge.

    Jim Dillan

    Hi Chris,

    I find it terrible that so many doctors won’t accept that parasites are a common problem that needs to be treated.

    It sounds like you have tried a lot of treatments and are well educated on the subject. I hope the papaya seed smoothie can work for you. If papayas are plentiful in your area I’d recommend doing the treatment every 2 weeks for at least 2 months to interrupt the breeding cycle. You can combine it with the other products you mentioned to hit them in multiple ways.

    Wishing you all the best in your healing.


Maria Belen

is it true sir that regular eating of ripe papaya can cause infertility to both husband and wife?why?thank you..it’s really a routine in our family that we will eat ripe papaya after eating meals…


Just found out that I’m allergic to pineapple and papaya, bummer! Especially so because a lot of my vitamins and such have bromelain and Papain- you are sourced from papaya and pineapple. I’m assuming that means I can’t have those, does anyone else know? I haven’t found any information on allergies and the sorts of digestive enzymes, everyone talks about how good they are for you, which they are! Unless you’re allergic…

    Jim Dillan

    Hi Amanda,

    Unfortunately people with these allergies are advised to avoid papain and bromelain.

    All the best,


L. Hicks

I take xarelto, can I eat the papaya seeds?


HI, I have A question. Can you eat evergthing or you have to do A no carb/sugar diet along with the smoothie?

    Jim Dillan

    Hi Lil,

    It’s definitely beneficial to limit added sugars in processed foods like high fructose corn syrup. The healthier you can eat while having the smoothie the more nutrition your body will have to fight back against parasites and bad bacteria.

    All the best,



Is there any other fruit I can use instead of pineapple? I can eat any other fruit, but fresh pineapple (not the canned pineapple) causes me to get awful mouth sores and digestive upsets.
May I use the canned pineapple instead, or is there a substitute?

    Jim Dillan

    Hi Karen,

    Papaya is the best replacement for pineapple for its digestive enzymes so you could simply add more of that. Kiwi fruit has good vitamin C but not the same digestive enzymes.

    If you get such a negative reaction to pineapple you may well be allergic to it.

    All the best,



Hi Jim ~

Have been avidly reading many of the articles on this site, and so appreciate your approach, thoughtful/careful responses and all the great info! I’m learning a lot! Thanks for all the work you put into this, and your great enthusiastic energy for informing us about this wonderful subject!

I’m commenting on this page about Papaya/papain enzyme warnings in relation to the info on Progesterone. I am enthusiastic about using the greenish papaya and seeds on a periodic basis for parasite cleansing, and following the protocol frequency mentioned but have some concern about the potential negative effect on body progesterone levels. For the last 6 years or so and I’m 60 now, I use progesterone cream (the only very good organic one from Organic Excellence) on a 3 week on, 1 week off basis. Older people, even men can benefit from some progesterone in its natural form as our bodies make much less or none as we age. Of course, everyone will be different in how much papain and periodic use of the parasite smoothie will affect their progesterone levels but just wondering if you have more info on specifics of that in particular? The idea I came up with is to drink or start a 4 day course of papaya smoothie for parasites during the progesterone off week, then only 1 or 2 the following week, skip and repeat after 2 weeks. There must be a way to have it all, but I think for most women using papain enzymes on any regular basis would not be a good idea as the effects of estrogen dominance and low progesterone is something to be avoided or remedied if one has that imbalance (likely in case of PMS).

I do appreciate that you cite everything, and have so many links in each article ~ very helpful!…. Has been a very deep rabbit hole for me but really fun to fall in as your site is pretty and also easy to read!

I would like to add one more thing here which may be of help to people, and maybe this can go other places on the site as well (or already is, don’t know)…. I want others to know about my wonderful natural health practitioner that has helped me many times over that last 10 years to overcome microbial issues, stay well, & be more well, (extremely important after traveling): James Reese inventor of The Reese Wellness System(.com) Especially recommended for helping people overcome bad microbes & parasites (most people today have an imbalanced ecosystem & inefficient immune system unless they have specifically addressed this) he helps you Reset/restore the body’s inner ecosystem, and so much more! There is no one like him that I have found!

    Jim Dillan

    Hi Christina and thank you for your positive and detailed comments.

    I think the papaya seed smoothie/progesterone therapy treatment cycle you’ve described sounds effective. The main concern, as I strongly advise in this article and the papaya seed one, is for pregnant women.

    I wouldn’t expect the papain in papaya seeds to directly affect progesterone treatment unless they were used at a similar time, though it does make good sense to have the smoothie on your off week. It’s hard to find conclusive information on this, but given also that the smoothie is only taken for a few days, rather than on an ongoing basis, and the effect is primarily in the digestive tract, I’d be surprised if there was an interaction days later. That said, I haven’t studied progesterone therapy treatment in detail so it would be good to check with an expert on it if you notice any negative effects.

    Appreciate your information on practitioners for parasites and acid reflux as well.

    All the best,




I have blasto hominis that I’m trying to rid. Just started on a organic colon cleanse (capsules and powder drink), it goes for approx 10 days. After that, will be doing similar to the Dr Hulda Clark cleanse for 16 days. During this time, can I do the papaya seed smoothie once a week? Im desperate to get rid of this!

Thanks for your help

    Jim Dillan

    Hi Samantha and sorry for the late reply as I’ve been away.

    I would think the papaya seed smoothie https://superfoodprofiles.com/papaya-seeds-parasites would work synergistically with this, though two or three days in a row would be more effective.

    If detox symptoms are too much try halving the dosage and slowly increasing the amount. As per the article doing this for several months, ideally every second weekend, is recommended to deal with the breeding cycle (though blasto hominis hopefully won’t take as long as intestinal worms).

    Also check the black walnut hull post https://superfoodprofiles.com/black-walnut-parasites-intestinal-worms for more information on parasite cleansing.

    All the best in your healing,



I live in the mountains of Peru and Giardia is one of those ‘everybody has it and we just have to learn to coexist’ type things here. I don’t coexist well with it. Would it be dangerous or inadvisable to just drink the parasite smoothie every morning as my breakfast? Perhaps with a smaller amount of papaya seeds? Papayas are really easy to come by and it would be nice to protect against the continual re-inoculation with the Giardia bugs.


    Jim Dillan

    Hi Aubrey,

    I’d think the papaya seed smoothie would be beneficial for controlling giardia, though you may only need it a couple of times a week as recommended in the article https://superfoodprofiles.com/papaya-seeds-parasites

    It’s a good idea to start off with a smaller amount of papaya seeds, perhaps just a teaspoon or so and slowly work up to the recommended tablespoon for parasite treatment over the following weeks, backing off on the dosage if you experienced side effects.

    Then again, if you’re having it regularly as a treatment you are probably fine with a bit smaller dosage.

    Have to admit I’m a bit jealous that papayas are so easy to come by there.

    All the best in your healing,



I do have the prothrombin mutation disease but I am not on any blood thinners. Would it be safe to take papaya enzymes?

    Jim Dillan

    Hi Michelle,

    It would be important to check with your physician on this as the papain in papaya enzymes may not be appropriate for people with prothrombin mutation disease or other blood clotting disorders.

    All the best,



I wish this information was more widely known. I did not know I had a latex allergy but was eating a lot of cooked green papaya then broke out in a rash. My doctors had been suggesting I take digestive papain enzymes for a gut disorder but I had a bad feeling about it so didn’t follow their advice. Now I am so glad I didn’t.

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