How Papaya Enzyme Benefits Digestion

Papaw enzymeWhile eating fruit after a meal isn’t generally recommended as it can have a negative effect on your digestion, papaya is one of the few exceptions

Papaya fruit is a rich source of valuable proteolytic enzymes, such as papain, that can greatly aid in the digestive process. This is especially true of meals that contain meat or other concentrated forms of protein.

However, as this page will show, papaya enzyme can have many other benefits and may have an even more important role to play when taken on an empty stomach.

Protein Digestion and Papaya Enzymes

Many of us eat large amounts of low quality meat each week that can put great strain on our digestive system and enzyme producing pancreas. Processed meats, with additives like sodium nitrite, are particularly worrying from a health perspective.


To make matters worse, rushed meals, extra large serving sizes, low digestive enzymes and stomach acid production, and poorly functioning digestive systems in general all contribute to this meat often ending up only partially digested by the time it reaches the lower intestine.

Here it can putrefy as it is acted upon by masses of flatulence causing bacteria. But smelly gas is the least of the potential problems caused by undigested protein in the colon.

The place to fix flatulence and other more serious issues associated with poor digestion, such as constipation and IBS, is not at the end of the process in the colon, but at the beginning.

Proper chewing is also important to break up food and can significantly assist carbohydrate digestion, but to get a head start on protein, proteolytic enzymes like the papain enzyme in papaya can really help.

What is Papain and What Does It Do?

The term proteolytic actually means protein digesting and, as an enzyme, papain is one of the most effective at breaking down meat and other proteins, comparable to the enzyme pepsin that we produce in our pancreas.

In fact, papain is often preferred to pepsin in scientific cell isolation procedures as it is considered a more effective enzyme. It is also used commercially as a meat tenderizer.

Papain works by cleaving the peptide bonds of complex proteins, breaking them down to their individual amino acids, ready for use in the growth and repair of your body.

Introducing papaya enzymes, like these papain rich green papaya ones I use, into a meal containing meat can significantly speed up its digestion.

It can also help with the breakdown of other ‘troublesome’ proteins, such as the gluten in wheat and the casein in milk, that often cause digestive problems.Green papaya enzymes

Papain Enzyme Beneficial Effects

Some people suggest that papain and other plant based enzymes would be destroyed in the hydrochloric acid of the stomach and see no value in them.

However, other nutritional experts believe that while papain may be rendered inactive with high levels of stomach acid, at least some would continue working again once it passes through to the alkaline environment of the small intestine.

Aside from these varying views, there is often a period, estimated at around half an hour to an hour, between when food is first eaten and when large amounts of hydrochloric acid is produced.

During this time, salivary enzymes and any plant-based enzymes in the food (or taken with it) begin the process of digestion. In this window of time the addition of papain into a meal can greatly increase protein breakdown.

Additionally, since papaya as a soft fruit doesn’t require much digestion itself, some of its enzymes may move into the small intestine before large amounts of stomach acid is produced.

Once in your intestines, papain and other papaya enzymes can help clear undigested protein-based debris and waste products.

Aside from helping to clear bloating and flatulence issues, proteolytic enzymes may also aid more serious digestive problems such as irritable bowel syndrome and help prevent fungal candida overgrowth in the gastrointestinal tract.

Green papayas for digestion

Why Green Papaya is Better for Digestion

Green fruit contain significantly more papaya enzyme than those that are fully ripened. That said, perhaps with the exception of green papaya salad, it’s not as appetizing for most people.

Bright orange fruits, aside from tasting sweeter, also contain more antioxidants and vitamins and have many other papaya benefits.

As a compromise, I personally use papayas that are just ripening but still have a little green on them. I’ll also use sections of fully green papaya in digestive and anti-parasite smoothies.

A convenient and potent alternative to eating papaya that is still green are green papaya supplements. Papain rich capsules like these can be taken with a meal high in protein and are an easy way to improve your digestion and avoid intestinal problems later on.

Taking Enzymes on an Empty Stomach

While green papaya enzymes are most often taken with food, another strategy that is gaining popularity is to have them blended up in a smoothie or with water on an empty stomach.

Under these circumstances little hydrochloric acid would be produced and the papain and other enzymes could pass into the small intestine in larger amounts.

From here they can be absorbed into your bloodstream where they exert an anti-inflammatory effect throughout the body.


Proteolytic enzymes circulating in the blood are known to reduce inflammation in your body, most likely by scavenging damaged and oxidized proteins and breaking them down.

These damaged proteins are implicated in a variety of debilitating autoimmune disorders such as severe allergies, chronic fatigue syndrome and a weakened immune system that is much more vulnerable to infections and disease.

The protein digesting enzymes from papaya fruit are generally recognized as safe and well tolerated when used internally. Despite their many benefits, there are some papaya enzyme precautions and a few potential papain side effects to be aware of which will be covered next.

Have you used green papaya enzymes before to improve your digestion or reduce inflammation in your body?

These papain rich green papaya capsules are the most potent I’ve found. They are highly effective when taken with a meal to improve digestive function, or alternatively as anti-inflammatory proteolytic enzymes on an empty stomach.

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